• Highest HbA1c reduction among pioglitazone-metformin combos
• Proven NASH & PCOS improvement
• Single evening dose for perfect adherence
• Strongest insulin-sensitising effect without hypos
• Most prescribed strength worldwide

1. One Zolid Plus 15/500mg tablet every evening with dinner
2. Swallow whole – do not crush or split
3. Doctor may increase to 30/500mg or 30/850mg if needed after 8–12 weeks
4. Continue long-term for sustained insulin-sensitivity benefits

Q1: Why is 15/850mg the most popular strength globally?
A1: It gives the strongest metformin effect while keeping pioglitazone at the safest 15mg dose – maximum sugar reduction with minimal fluid retention.

Q2: How much HbA1c drop can I expect?
A2–2.4% average reduction when baseline is >9% – one of the highest drops achievable with oral dual therapy.

Q3: Is it helpful for fatty liver disease?
A3: Yes – pioglitazone 15mg is the only oral diabetes drug with Level-A evidence for histological improvement in biopsy-proven NASH.

Q4: Will I get swollen ankles?
A4: Mild leg oedema occurs in ~5–7% (much less than 30mg dose); usually resolves or stays tolerable.

Q5: Can women with PCOS use it?
A5: Highly effective off-label – restores ovulation in 50–70% of anovulatory PCOS women within 3–6 months.

• Take once daily with evening meal to maximise tolerance
• Doctor will monitor weight, liver enzymes & signs of fluid retention
• Avoid in active heart failure (NYHA class III–IV) or bladder cancer history
• Stop temporarily before major surgery or iodinated contrast procedures
• Keep away from children