• Directly treats insulin resistance at its source
• Extra 0.8–1.4% HbA1c drop on top of metformin
• Proven benefits in fatty liver & PCOS
• Once-evening convenient dosing
• Lowest fluid-retention risk strength

1. One Zolid Plus 15/500mg tablet every evening with dinner
2. Swallow whole – do not crush or split
3. Doctor may increase to 30/500mg or 30/850mg if needed after 8–12 weeks
4. Continue long-term for sustained insulin-sensitivity benefits

Q1: Why add pioglitazone when metformin alone isn’t enough?
A1: Pioglitazone directly fixes insulin resistance in liver & muscle – dropping fasting glucose & HbA1c by an extra 0.8–1.4% with minimal hypo risk.

Q2: Will I gain weight like with older diabetes medicines?
A2: Usually 1–3 kg fluid-related gain in first months (mostly in legs), then stabilises; many patients later lose weight when combined with lifestyle changes.

Q3: Is it safe for fatty liver or PCOS?
A3: Yes – pioglitazone is one of the few oral medicines proven to reduce liver fat and improve ovulation in PCOS.

Q4: When is 15/500mg preferred over 30mg strengths?
A4: Starter & maintenance dose for most patients – gives excellent results with lowest risk of fluid retention.

Q5: Any heart concerns?
A5: Contraindicated in active heart failure; safe and widely used in patients with stable coronary disease.

• Take once daily with or after evening meal (reduces GI upset)
• Regular weight & liver-function monitoring in first year
• Not for type-1 diabetes or history of heart failure
• Stop 48 hours before planned surgery or contrast scans
• Keep away from children