• Dual mechanism attacks insulin resistance and glucose production simultaneously
• Greater HbA1c reduction than metformin or pioglitazone alone
• Convenient single-tablet therapy improves adherence
• Supports beta-cell preservation and long-term diabetes management
• Once- or twice-daily dosing fits easily into daily routine

1. Take Piozer Plus 15/500mg Tablet with meals to reduce stomach upset (usually breakfast and/or dinner)
2. Swallow whole with water; do not crush, chew, or break the tablet
3. Start with once daily and increase to twice daily if prescribed by your doctor
4. If you miss a dose, take it with the next meal—never double up
5. Continue diet, exercise, and regular blood sugar monitoring alongside treatmentTake Piozer Plus 15/500mg Tablet with meals to reduce stomach upset (usually breakfast and/or dinner)
6. Swallow whole with water; do not crush, chew, or break the tablet
7. Start with once daily and increase to twice daily if prescribed by your doctor
8. If you miss a dose, take it with the next meal—never double up
9. Continue diet, exercise, and regular blood sugar monitoring alongside treatment

Q1: Why combine pioglitazone and metformin?
A1: They work through different mechanisms for stronger, more complete blood sugar control than either alone.

Q2: Can I switch directly from separate tablets to Piozer Plus?
A2: Yes, your doctor can switch you to this equivalent-dose combination for convenience.

Q3: Will I experience stomach issues?
A3: Mild nausea or diarrhea may occur initially due to metformin; symptoms usually improve within weeks.

Q4: How much can HbA1c drop with Piozer Plus?
A4: Studies show average reductions of 1–2% when added to existing therapy.

Q5: Is weight gain expected?
A5: Pioglitazone may cause slight weight increase, but metformin usually helps keep weight neutral or lower.

• Not for type 1 diabetes or diabetic ketoacidosis
• Risk of lactic acidosis (rare but serious); report unexplained nausea, muscle pain, or breathing difficulty immediately
• Inform your doctor if you have heart failure, liver/kidney disease, or history of bladder cancer
• May cause fluid retention; monitor for swelling or rapid weight gain
• Temporary gastrointestinal upset is common when starting metformin—take with meals to reduce
• Store below 25°C in a dry place, away from children