• Strongest oral insulin-sensitiser + secretagogue combo available
• Up to 3.1% HbA1c reduction – often delays insulin start
• Top-choice for severe NAFLD/NASH with diabetes
• Once-morning dosing convenience
• Maximum fasting glucose correction

1. One Zoliget 30/2mg tablet every morning with first meal
2. Swallow whole with water
3. Eat regular meals – do not skip
4. Usually the final oral step before starting insulin

Q1: When does the doctor prescribe the 30mg pioglitazone strength?
A1: High baseline HbA1c (>10%), severe insulin resistance, NAFLD/NASH needing aggressive liver improvement, or failure on lower doses/combos.

Q2: How much stronger is 30/2mg than 15/2mg?
A2: Adds another 0.6–1.0% HbA1c drop and far greater fasting glucose reduction – often the difference between staying on tablets vs needing insulin.

Q3: Is it still safe for fatty liver?
A3: Yes – 30–45mg pioglitazone has the strongest evidence for reversing NASH histology (better than 15mg).

Q4: Will I gain a lot of weight?
A4: Average +3–6 kg in first year (mostly fluid + subcutaneous fat); manageable with low-salt diet and mild diuretic if needed.

Q5: Can I switch straight from 15/2mg to 30/2mg?
A5: Yes – same glimepiride dose, just doubled pioglitazone effect for extra power.

• Take once every morning with breakfast (never on empty stomach)
• Higher risk of mild–moderate hypoglycaemia – always carry fast-acting sugar
• Monitor for weight gain & ankle swelling (pioglitazone 30mg effect)
• Contraindicated in heart failure, active bladder cancer, or severe liver disease
• Keep away from children