• Same life-saving ARNI technology in the gentlest possible dose
• 20% lower risk of CV death & 21% fewer hospitalisations
• Perfect starter for elderly & sensitive patients
• Twice-daily easy routine
• Proven first-line HFrEF therapy worldwide

1. Take one Savesto 50mg tablet twice daily (morning + evening)
2. Swallow whole with water – food optional
3. Most patients start here and step up to 100mg or 200mg after 2–4 weeks if tolerated
4. Lifelong therapy for HFrEF (ejection fraction ≤40%)
5. Doctor will guide safe up-titration

Q1: Why start with 50mg instead of 100mg or 200mg?
A1: Safest introduction for elderly, low BP, kidney impairment, or South-Asian patients who are more sensitive to BP drop.

Q2: Is the 50mg dose still powerful enough?
A2: Yes – even the lowest dose showed the same 20% survival benefit in major trials when titrated properly.

Q3: How soon can I move to the higher strength?
A3: Usually after 2–4 weeks if BP stays stable and no side effects.

Q4: Can I break the tablet if I can’t swallow it whole?
A4: No – film-coated; must be swallowed whole (or switch to suspension form if available).

Q5: Why is it labelled 50mg when it says 24/26mg?
A5: 50mg is the total of sacubitril + valsartan (24 + 26 = 50).

• 36-hour washout required after stopping ACE inhibitors
• Regular monitoring of BP, potassium, and kidney function
• Not to be combined with ACE inhibitors or aliskiren
• Caution if history of angioedema
• Keep away from children