• High-dose metformin + pioglitazone for maximum HbA1c lowering
• Targets insulin resistance and glucose production at the same time
• Convenient fixed-dose tablet reduces pill burden
• Proven synergy for patients not at goal on metformin alone
• Supports long-term beta-cell function preservation

1. Take Piozer Plus 15/850mg Tablet with meals (usually breakfast and dinner) to reduce gastrointestinal side effects
2. Swallow the tablet whole with water; do not crush, chew, or split
3. Follow your doctor’s dosing—commonly one tablet twice daily
4. If you miss a dose, take it with your next meal—never double the dose
5. Keep up regular blood sugar testing, healthy eating, and physical activity

Q1: Why choose the 15/850mg over the 15/500mg version?
A1: The higher 850mg metformin dose provides stronger glucose-lowering power when tighter control is needed.

Q2: Will this cause more stomach upset than lower doses?
A2: Possibly at first—taking with food and gradual dose increase helps most patients adjust.

Q3: How much can HbA1c drop with Piozer Plus 15/850mg?
A3: Clinical studies show reductions of 1.5–2.5% when added to previous therapy.

Q4: Can I switch directly from separate pioglitazone and metformin tablets?
A4: Yes, your doctor can switch you to this equivalent-strength combination for simplicity.

Q5: Is weight gain common?
A5: Pioglitazone may cause mild gain due to fluid, but metformin usually helps keep overall weight stable.

• Not suitable for type 1 diabetes or diabetic ketoacidosis
• Rare but serious risk of lactic acidosis—seek immediate help for vomiting, muscle pain, or rapid breathing
• Inform your doctor if you have kidney/liver disease, heart failure, or history of bladder cancer
• May cause fluid retention; watch for sudden swelling, weight gain, or shortness of breath
• Take with meals to minimize stomach upset from metformin
• Store below 25°C in a dry place, away from children