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Savesto 100mg/49mg/51mg Tablet

Savesto 100/49/51mg Tablet 28s – Sacubitril 49mg + Valsartan 51mg (100mg total)

  • Sacubitril 49mg + Valsartan 51mg (100mg) ARNI tablet
  • Life-saving heart failure treatment
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Sale price Rs.2,090.00 PKR
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Savesto 100mg/49mg/51mg Tablet
Savesto 100/49/51mg Tablet 28s – Sacubitril 49mg + Valsartan 51mg (100mg total)
Sale priceRs.2,090.00 PKR
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Categories: Medicines Tablets & Capsules
Tags: Entresto Generic Heart Failure ARNI Sacubitril Valsartan Savesto 100
Savesto 100mg/49mg/51mg Tablet

Savesto 100/49/51mg Tablet 28s – Sacubitril 49mg + Valsartan 51mg (100mg total)

Rs.2,090.00

Savesto 100mg (49/51) Tablet – Revolutionary ARNI Therapy that Reduces Heart-Failure Deaths by 20%

Savesto 100mg is the low-to-mid strength of Sacubitril 49mg + Valsartan 51mg (labelled as 100mg total) – the world’s first and only Angiotensin Receptor-Neprilysin Inhibitor (ARNI). By blocking harmful angiotensin II while boosting protective natriuretic peptides, it dramatically lowers strain on a failing heart, reduces hospitalisations by 21%, and extends life expectancy more than old ACE inhibitors. Prescribed for HFrEF (ejection fraction ≤40%) in NYHA class II–IV patients who remain symptomatic on ACEi/ARB/beta-blocker therapy.

  • 20% reduction in cardiovascular death vs old ACE inhibitors
  • 21% fewer heart-failure hospitalisations
  • Improves symptoms, exercise capacity & quality of life
  • Twice-daily simple dosing
  • Gold-standard HFrEF therapy worldwide

  1. Take one Savesto 100mg tablet twice daily (morning + evening)
  2. Swallow whole with water – with or without food
  3. Start on 100mg (49/51) if previously on low-dose ACEi/ARB or if elderly/small-framed
  4. Doctor may increase to 200mg (97/103) twice daily after 2–4 weeks if tolerated
  5. Lifelong therapy unless advised otherwise

Q1: How is Savesto different from ordinary blood-pressure tablets?
A1: It’s an ARNI – blocks harmful hormones AND boosts heart-protective hormones; proven to prolong life in heart failure.

Q2: Why is it labelled 100mg when it’s 49/51mg?
A2: The number (100mg) is the total of sacubitril + valsartan; actual strengths are 49mg sacubitril + 51mg valsartan.

Q3: Will it make my blood pressure drop too much?
A3: Possible at start – doctors usually begin with 100mg strength and monitor closely.

Q4: Can I switch directly from enalapril or losartan?
A4: Yes – after a 36-hour washout for ACE inhibitors; ARBs can switch directly.

Q5: Is it safe long-term?
A5: Yes – PARADIGM-HF trial showed superior survival and safety over 10+ years of follow-up.

Sacubitril 49mg, Valsartan 51mg, Microcrystalline Cellulose, Crospovidone, Magnesium Stearate, Talc, Colloidal Silicon Dioxide, Hypromellose, Titanium Dioxide, Macrogol, Iron Oxide Red

  • Do not start within 36 hours of stopping an ACE inhibitor (angioedema risk)
  • Monitor blood pressure, potassium, and kidney function regularly
  • Not for use with ACE inhibitors or aliskiren
  • Caution in severe liver disease or history of angioedema
  • Keep away from children

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