• Significantly prolongs “on” time and reduces motor fluctuations
• Allows lower total daily Levodopa dose with better efficacy
• Fewer tablets per day compared to separate medications
• Improves walking, tremor, rigidity, and daily activities
• Proven long-term benefit in advanced Parkinson’s diseaseSignificantly prolongs “on” time and reduces motor fluctuations
• Allows lower total daily Levodopa dose with better efficacy
• Fewer tablets per day compared to separate medications
• Improves walking, tremor, rigidity, and daily activities
• Proven long-term benefit in advanced Parkinson’s disease

1. Take exactly as prescribed by your neurologist, usually 3–6 times daily with or without food
2. Swallow the tablet whole with water – do not crush, chew, or break
3. Maintain consistent timing and protein spacing (high-protein meals may reduce absorption)
4. Never double the dose if you miss a dose – take the next dose at the scheduled time
5. Attend regular follow-ups for dose adjustments and monitoring of motor/non-motor symptoms

Q1: Why is Entacapone added to Levodopa/Carbidopa?
A1: Entacapone extends the effect of each Levodopa dose by 30–50%, reducing wearing-off and daily tablet count.

Q2: Can I cut or crush Dopacone tablets?
A2: No – the tablet must be swallowed whole to maintain proper release and effectiveness.

Q3: Will this medicine make me sleepy during the day?
A3: Some patients experience sudden sleep episodes; avoid driving until you know how it affects you.

Q4: How soon will I feel improvement?
A4: Most patients notice smoother movement and fewer “off” periods within 1–2 weeks of stable dosing.

Q5: Is urine or sweat colour change normal?
A5: Yes – harmless dark reddish-brown discoloration of urine/sweat is common with this combination.

• Do not use if you have narrow-angle glaucoma, malignant melanoma, or history of neuroleptic malignant syndrome
• Avoid sudden discontinuation – may cause serious worsening or hyperpyrexia
• May cause drowsiness or sudden sleep attacks – do not drive or operate machinery if affected
• Monitor for impulse control disorders (gambling, hypersexuality, compulsive shopping)
• Inform your doctor if you have severe cardiovascular, liver, kidney, or psychiatric conditions
• Store below 30°C in a dry place; keep away from children