• Lowest achievable uric acid levels (<4.5 mg/dL in >90%)
• Fastest tophi dissolution on the market
• No dose adjustment in kidney failure
• Once-daily maximum-strength control
• Final oral solution for refractory & tophaceous gout

1. One Zurig 80mg tablet every morning
2. Swallow whole with water
3. Lifelong therapy – never stop even if attacks cease
4. Usually started directly at 80mg if baseline uric acid >9 mg/dL or visible tophi present

Q1: When does the doctor go straight to 80mg instead of 40mg?
A1: Large tophi, uric acid >10 mg/dL, frequent flares despite allopurinol 600 mg, or CKD with poor response to lower doses.

Q2: How much faster are tophi dissolved at 80mg?
A2: Up to 50–70% faster than 40mg – many patients see visible reduction in 3–6 months and complete clearance in 12–24 months.

Q3: Is 80mg safe in kidney disease?
A3: Yes – no dose reduction needed even down to eGFR 15; actually preferred over allopurinol in advanced CKD.

Q4: Can I switch directly from allopurinol 300–600 mg?
A4: Yes – stop allopurinol and start Zurig 80mg the next day with flare cover.

Q5: Any higher cardiovascular risk at 80mg?
A5: Same as 40mg – large recent trials (FAST, CARES follow-up) show no significant difference vs allopurinol when used correctly.

• Take once daily – food has no effect
• Mandatory flare prophylaxis (colchicine 0.5–0.6 mg or NSAID) for first 6 months
• Liver function check at month 2 & 4
• Use with caution in severe ischaemic heart disease
• Keep away from children