• Highest-dose ARB + CCB single-pill combo
• 28–38 mmHg average systolic BP reduction
• Proven kidney & heart protection (ONTARGET-level evidence)
• Once-morning simplicity
• First choice for resistant & very-high-risk hypertension

1. One Tasmi AM 10/80mg tablet every morning at the same time
2. Swallow whole – do not crush or split
3. Most patients stay on this strength long-term once titrated
4. Final oral step before adding a third agent (e.g. diuretic)

Q1: When is the 80/10mg strength prescribed instead of lower doses?
A1: Office BP ≥160/100, resistant hypertension, diabetic kidney disease, thick heart muscle (LVH), or known stroke history – anywhere maximum BP lowering + organ protection is critical.

Q2: How much stronger than Telmisartan 80mg or Amlodipine 10mg alone?
A2: Adds another 10–15 mmHg systolic drop – the biggest additive effect of any ARB + CCB pair.

Q3: Will I get swollen ankles from the high amlodipine?
A3: Occurs in ~8–12%; telmisartan actually reduces swelling compared to amlodipine alone.

Q4: Safe in chronic kidney disease?
A4: Yes – telmisartan 80mg is proven kidney-protective (reduces proteinuria by 30–40%) even down to eGFR 30.

Q5: Can I switch straight from separate tablets?
A5: Absolutely – identical doses in one convenient pill with better 24-hour coverage.

• Take once every morning – with or without food
• Stand up slowly first few days to avoid light-headedness
• Monitor kidney function & potassium at 2–4 weeks
• Not in pregnancy (category D)
• Keep away from children