Home Advantec 16/12.5mg Tablet – Once-Daily High-Dose Candesartan + Diuretic for Resistant & High-Risk Hypertension
Advantec 16/12.5mg Tablet
Advantec 16/12.5mg Tablet
Advantec 16/12.5mg Tablet
Advantec 16/12.5mg Tablet

Advantec 16/12.5mg Tablet – Once-Daily High-Dose Candesartan + Diuretic for Resistant & High-Risk Hypertension

  • Candesartan 16mg + HCTZ 12.5mg once-daily tablet
  • Maximum ARB + diuretic power for resistant & kidney-related BP
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Sale price Rs.1,200.00 PKR
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Advantec 16/12.5mg Tablet
Advantec 16/12.5mg Tablet – Once-Daily High-Dose Candesartan + Diuretic for Resistant & High-Risk Hypertension
Sale priceRs.1,200.00 PKR
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Categories: Medicines Tablets & Capsules
Tags: Advantec 16/12.5 Atacand Plus Generic Candesartan HCTZ Resistant Hypertension
Advantec 16/12.5mg Tablet

Advantec 16/12.5mg Tablet – Once-Daily High-Dose Candesartan + Diuretic for Resistant & High-Risk Hypertension

Rs.1,200.00

Advantec 16/12.5mg Tablet – Candesartan Cilexetil 16mg + Hydrochlorothiazide 12.5mg Potent ARB + Diuretic Single-Pill Combo

Advantec 16/12.5mg is the strongest candesartan-based fixed-dose combination, pairing a powerful 16mg ARB (candesartan – the longest-acting in its class) with a proven 12.5mg diuretic (HCTZ). One morning tablet delivers an extra 12–18 mmHg systolic drop compared to candesartan alone, routinely bringing resistant hypertension, diabetes with proteinuria, chronic kidney disease, or post-stroke patients to target <130/80. This is the preferred upgrade when candesartan 32mg monotherapy still leaves BP above goal.

  • Strongest candesartan + diuretic single-pill combo
  • 12–18 mmHg extra systolic drop vs candesartan alone
  • Proven kidney & stroke protection
  • Once-morning convenience
  • First choice upgrade for resistant & diabetic hypertension

  1. One Advantec 16/12.5mg tablet every morning at the same time
  2. Swallow whole – do not split or crush
  3. Most patients stay on this strength long-term
  4. Final oral step before adding spironolactone or beta-blocker

Q1: When is 16/12.5mg chosen instead of candesartan 32mg alone?
A1: Office BP still ≥140/90 on candesartan 32mg, diabetic proteinuria, CKD stage 3, or any high-risk case needing maximum non-ACEi lowering.

Q2: How much extra BP drop does the HCTZ add?
A2: 12–18 mmHg systolic & 6–10 mmHg diastolic on top of candesartan 16mg – one of the largest additive effects in ARB + diuretic pairs.

Q3: Will it cause low potassium or gout?
A3: Mild potassium drop possible (rarely symptomatic); gout risk is very low at 12.5mg HCTZ dose.

Q4: Safe in kidney disease?
A4: Yes – candesartan is proven kidney-protective (reduces proteinuria 30–40%) down to eGFR ≥30.

Q5: Can I switch straight from candesartan 32mg alone?
A5: Yes – stop 32mg and start Advantec 16/12.5mg next morning (same total ARB exposure + diuretic boost).

Candesartan Cilexetil 16mg, Hydrochlorothiazide 12.5mg, Lactose Monohydrate, Microcrystalline Cellulose, Magnesium Stearate, Opadry Pink

  • Take once every morning – with or without food
  • Stand up slowly first week to avoid dizziness
  • Check kidney function & potassium at 2–4 weeks
  • Not during pregnancy (category D)
  • Keep away from children

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